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Tat‐interactive protein 60 consists of an N‐terminal chromo barrel domain (TIP60‐CB) and a C‐terminal acetyltransferase domain and acetylates histone and nonhistone proteins in diverse cellular processes. While TIP60‐CB is thought to recognize histone tails, molecular details of this interaction remain unclear. Here, we attempted a quantitative analysis of the interaction between the human TIP60‐CB...
Thioredoxin‐interacting protein (TXNIP) is a multifunctional protein involved in diverse cellular processes such as cell proliferation and apoptosis. TXNIP stability is controlled by the ubiquitin–proteasome pathway, and the E3 ubiquitin ligase Itch directly interacts with TXNIP via PPxY motifs of TXNIP. In a previously published study, we have shown that phosphorylation of the PPxY tyrosyl residue...
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