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To investigate complex electrophysiological behaviour (such as reentrant cardiac arrhythmias) in the setting of the complex anatomy of the heart, the use of a simplified model is computationally more effective. In this study, the Rogers-modified FitzHugh-Nagumo model was further modified to allow control of action potential upstroke velocity, conduction velocity, action potential duration and refractory...
Remarkable differences in action potential properties between the Purkinje fibre and ventricular cells may lead to abnormalities in excitation conduction through the Purkinje-ventricular junction (PVJ) and arrhythmogenic behaviour. We develop a family of electrophysiologically detailed computer models for rabbit epicardial, midmyocardial and endocardial ventricular myocytes, as well as the rabbit...
In both human and animal mammals, the pacemaker of the heart, the sinoatrial node (SA node), deteriorates with age. The main features of the aged SA nodes are a slow pacemaking rate and possible SA node-atrium conduction exit block or arrest of SA node pacemaking (i.e., termination of the SA node pacemaker activity). The mechanisms underlying the age-related dysfunction of the heart are unclear. In...
The electrocardiogram (ECG) is an important index of clinical diagnosis of cardiac arrhythmias. Simulations of ECG had revealed the causative relationship between waveforms of ECG and action potentials (APs). However, those studies were mainly based on the Luo-Rudy (LRd) model or the Priebe-Beuckelman (PB) model. In this study, we developed a ID model of transmural ventricular strand based on the...
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