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The E1784K mutation in SCN5A was reported as a phenotypic overlap between the Type 3 Long QT syndrome (LQT3) and the Brugada syndrome (BrS). However it is still unclear if the E1784K mutation-induced changes at ionic channel level is sufficient to account for the two phenotypic and how they affect ventricular excitation waves at tissue level. In this study, we used a biophysically detailed computer...
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