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In article number 1804730, Eli D. Sone and co‐workers report on the development of biomimetic collagen scaffolds that incorporate bone‐like mineralized layers alongside unmineralized layers, resembling hard‐soft connective tissue interfaces. The boundary between mineralized and unmineralized layers is well defined, with unmineralized collagen fibrils intermingling with the mineralized layer to create...
Hard–soft tissue interfaces pose unique challenges for regeneration due to architectural, mechanical, and compositional changes between tissues, which are difficult to incorporate into tissue engineering scaffolds. Multiphasic scaffolds are needed to better mimic structural and chemical changes through the incorporation of layers with distinct properties. A particular challenge in the production of...
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