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The efficient induction of virus-specific mucosal antibodies is an important unmet objective in Human Immunodeficiency Virus Type-1 (HIV-1) vaccine research. One promising approach is sublingual (SL) immunization. We examined the effectiveness of SL delivery of two different viral vectors: (i) a recombinant adenovirus (rAd5), and (ii) a Herpes Simplex Virus Type-1 amplicon vector (HSV-1). Initial...
Parkinson's disease (PD) is a neurodegenerative illness of unknown etiology that presently has no cure. Symptoms of this progressively debilitating disease include bradykinesia, resting tremor, rigidity, gait abnormalities, and postural instability that can be transiently alleviated via continued administration of the drug, L-DOPA. However, following prolonged usage, the effectiveness of this clinical...
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