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Complement opsonization is among the biggest challenges facing nanomedicine. Nearly instantly after injection into blood, nanoparticles are opsonized by the complement protein C3, leading to clearance by phagocytes, fouling of targeting moieties, and release of anaphylatoxins. While surface polymers such as poly(ethylene glycol) (PEG) partially decrease complement opsonization, most nanoparticles...
Nanomedicine
Immediately upon encountering blood, nanoparticles are attacked by complement proteins. Complement binding produces an anaphylaxis‐like reaction and causes nanoparticles to be cleared from circulation by phagocytes. To defend nanoparticles, in article number 2107070, Jacob W. Myerson, Jacob S. Brenner, and co‐workers demonstrate how to conjugate nanoparticles to humans' natural complement...
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