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Chick embryos were treated with single or multiple doses of 0–250 pmol of endothelin-1 (ET-1) or endothelin-3 (ET-3) and their effects on development were examined in embryos ranging from 7 to 14 days in age. The overall sizes of the head, trunk, beak or wings were increased (5–14%) in ET-treated embryos. Additionally, the lengths or widths of the telencephalic or optic lobes and the diencephalon...
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