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Interleukin (IL)-36 cytokines belong to the IL-1 family and include three agonists, IL-36 α, β and γ and one inhibitor, IL-36 receptor antagonist (IL-36Ra). IL-36 and IL-1 (α and β) activate similar intracellular pathways via their related heterodimeric receptors, IL-36R/IL-1RAcP and IL-1R1/IL-1RAcP, respectively. However, excessive IL-36 versus IL-1 signaling induces different phenotypes in humans,...
IL-36 cytokines belong to the IL-1 family and include three agonists, IL-36 α,β and γ and one inhibitor, IL-36Ra. IL-36 is expressed in activated epithelia and in hematopoietic tissues, and activates keratinocytes and dendritic cells (DC) via its receptor, IL-36R. IL-36 also stimulates Th1 polarization in mice.To analyze the expression of IL-36R in circulating and tonsil human immune cells and to...
IL-36α, IL-36β and IL-36g are members of the IL-1 family of cytokines which bind to the IL-36R leading to recruitment of the IL-1 receptor accessory protein (IL-1RAcP) to initiate signal transduction. IL-36Ra is a natural antagonist of IL-36 and mutations in the IL-36Ra gene have been shown to be causative for a severe form of psoriasis, generalized pustular psoriasis. IL-36 is believed to initiate...
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