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To observe the effects of PI3-K, MAPKs and JNK on APP α metabolism treated with exogenous hydrogen sulfide (H 2 S) and Donepezil in PC12 cell.PC12 cell were cultured in vitro and NaHS were exogenous H 2 S donor. Cells were pretreated with SP600125 (SP, JNK inhibitor 20μM), LY294002 (LY, PI3-K inhibitor, 20μM) or SB203580 (SB, MAPK inhibitor, 30μM), before NaHS (100μM) or Donepezil...
To observe the effect of exogenous hydrogen sulfide (H 2 S) and Donepezil on surviving rate in pheochromocytoma cells (PC12 cells) treated with beta amyloid peptide 25–35 (Aβ25–35).PC12 cells were cultured in vitro and sulfur hydrogenated sodium (sodium hydrosulfide, NaHS) was used as exogenous H 2 S donor. The cells were divided into six groups: control group, Aβ25–35 group, NaHS...
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