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We report the first real-time biomechanical measurement of DNA bundle degradation in stable condition when exposed to a therapeutic radiation beam and a theoretical model to describe DNA damages. The Silicon Nano Tweezers and their new microfluidic system endure the harsh environment of radiation beams and still retain molecular-level accuracy. This result paves the way for both fundamental and clinical...
In this research, we demonstrate for the first time the in-situ polymerization and the mechanical characterization of metallopolymer wires by MEMS Silicon Nanotweezers. Metallopolymers have interesting semiconductor characteristics that can be tuned by polymerization conditions. The reported method allows the experiment of various polymerization conditions with a high versatility such as the metallopolymer...
This paper describes an integrated bio-reaction platform composed of silicon nanotweezers and open microfluidics for real time biomechanical assays. The silicon nanotweezers can sense slight biological modification of the trapped sample due to stable frequency response with high Q factor in liquid. The microfluidic device integrates active valves for controlling the biological medium. Biomolecular...
This paper demonstrates the real-time sensing of enzymatic reactions on a DNA bundle trapped by silicon nanotweezers. The digestion of DNA in protein solution (Hind III) is monitored by tracking the change in frequency response of the immersed tweezers. This new direct biomechanical detection clears the way for systematic bio tests at the molecular level by an integrated MEMS device.
We describe a MEMS-based method for the biomechanical characterization of filamentary molecules. The system consists of a pair of electrostatically actuated silicon nanotweezers and a differential capacitive sensor that is connected to the moving tip of the tweezers. With such a tool, we achieved sub-nanometer displacement resolution (around 0.2 nm), detected the trapping of DNA nanowires and measured...
This paper deals with the first simultaneous electrical and mechanical characterization of DNA bundles by a MEMS tool. The silicon-based device has an integrated actuator and a differential capacitive position sensor. Our experiments show that under constant humidity conditions, a rope of DNA has a nearly Ohmic conductivity and behaves as a viscoelastic material.
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