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We developed a new type of a microcantilever biosensor resonating at the interface between air and liquid. The cantilever sensor has advantages in high signal-to-noise ratio (SNR) and high quality factor (Q-factor) for detecting bio-reactions because liquid damping acts on only one-side, and because there is no obstacle between detection, excitation lasers and the cantilever. (Fig. 1 (c)) Using the...
Despite the benefits of miniaturized devices, handling of tiny amount of molecules became a great challenge. Direct transport, similar to the one in intracellular transport, is a way to cope with the problem of transporting tiny amount of materials. Using motor proteins, i.e. kinesin, and the corresponding rail structures, i.e. microtubules, provides powerful building blocks for a nanotransport system...
Linear Brownian motors utilize relatively weak electric fields to bias the diffusion of particles in a microfluidic channel thereby harnessing Brownian motion to facilitate particle transport. We present a custom simulator for such a system and use it to optimize transport by modifying the electrode configuration and rectification scheme. With insight gained from simulation, we are able to identify...
The microorganism, vorticella, of about 50 mum in diameter was found to be capable of mixing beads in microfluidic channel by energizing vortex with its cilia. Vortex generation and flow velocity around the cell body of a vorticella was experimentally studied using both fluorescents and non-fluorescents microbeads of different size (from 0.5 to 20 mum in diameter). Two vortices in two-dimensional...
We report on fabrication and experimental characterization of a linear Brownian motor with a periodic 3-phase electrostatic rectification for unidirectional transport of nanobeads in microfluidic channels. The transport of the beads is performed in 1 mum deep, 2 mum wide PDMS microchannels, which constrain three-dimensional random motion of nanobeads into ID fluctuation, so-called tamed Brownian motion...
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