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Neutrophil Mechanophenotyping
The intrinsic biophysical states of neutrophils are often associated with immune dysfunctions. In article number 2104822, Han Wei Hou and co‐workers report an “optics‐free” microfluidic biophysical cytometer for impedance‐based single cell electro‐mechano‐phenotyping. The developed platform integrates elasto‐inertial focusing, hydrodynamic cell pinching, and multifrequency...
The intrinsic biophysical states of neutrophils are associated with immune dysfunctions in diseases. While advanced image‐based biophysical flow cytometers can probe cell deformability at high throughput, it is nontrivial to couple different sensing modalities (e.g., electrical) to measure other critical cell attributes including cell viability and membrane integrity. Herein, an “optics‐free” impedance‐deformability...
Non‐invasive and real‐time monitoring of microcarriers and three‐dimensional cell cultures are important in biomanufacturing and bioprocesses. In article number 2007500, Han Wei Hou and co‐workers introduce a low‐cost microfluidic impedance cytometer with Field's metal electrodes for label‐free and continuous‐flow monitoring of spheroids/microcarriers based on changes in impedance signatures. Potential...
3D cellular spheroids/microcarriers (100 µm–1 mm) are widely used in biomanufacturing, and non‐invasive biosensors are useful to monitor cell quality in bioprocesses. In this work, a novel microfluidic approach for label‐free and continuous‐flow monitoring of single spheroid/microcarrier (hydrogel and Cytodex) based on electrical impedance spectroscopy using co‐planar Field's metal electrodes is reported...
Circulating leukocytes comprise of approximately 1% of all blood cells and efficient enrichment of these cells from whole blood is critical for understanding cellular heterogeneity and biological significance in health and diseases. In this work, we report a novel microfluidic strategy for rapid (< 1 h) label-free leukocyte sorting and impedance-based profiling to determine cell activation in type...
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