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During distraction osteogenesis, new and highly vascularized bone is formed, with angiogenesis preceding osteogenesis. We investigated the possibility that COMP–Ang1, an angiogenic factor, may facilitate bone formation.Rats were divided into three groups. Control rats underwent tibial distraction without treatment. In the two remaining groups, BSA (100μg) or COMP–Ang1 (100μg) were injected transcutaneously...
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