Search results for: Guodong Yang

Items from 1 to 20 out of 122 results

article

Lysosome‐Targeting Bacterial Outer Membrane Vesicles for Tumor Specific Degradation of PD‐L1 (Small 43/2024)

Panpan Ji, Pengying Wu, Lantian Wang, Yufei Wang, more

Small > 20 > 43 > n/a - n/a

Tumor Therapy In article number 2400770, Fan Lu, Guodong Yang, Gang Ji, and co‐workers developed an outer membrane vesicle (OMV)‐based nanosystem to unleash the anti‐tumor immunity via targeted degradation of PDL1. The tumor homing OMVs derived from engineered bacteria are empowered to trigger PDL1 degradation after simply absorbing dual ligands for lysosome‐targeting receptor and PDL1. The proposed...

article

Lysosome‐Targeting Bacterial Outer Membrane Vesicles for Tumor Specific Degradation of PD‐L1

Panpan Ji, Pengying Wu, Lantian Wang, Yufei Wang, more

Small > 20 > 43 > n/a - n/a

Increased expression of immune check point genes, such as PD‐L1, is one of the main reasons for immunosuppression, especially for colon cancer. Development of novel therapeutic strategies is of great importance to improve the prognosis. In this study, outer membrane vesicles (OMV) derived from Gram‐negative bacteria are engineered to immune checkpoint blockade nanosystem for efficient elicitation...

article

Laser‐induced self‐propagating synthesis and electromagnetic wave absorption properties of MoAlB powders

Tao Li, Houbo Xie, Guodong Yang, Jinbo Wu, more

Journal of the American Ceramic Society > 107 > 9 > 6180 - 6191

MoAlB powders with a purity of 96 wt.% were successfully fabricated by a laser‐induced self‐propagating method using molybdenum boride (MoB) and aluminum powders as starting materials under the conditions of an n(MoB): n(Al) ratio of 1.0:1.4 and the laser linear energy density (E_l) of 0.9 J/mm, and the effect of raw material composition and E_l on the phase composition and microstructure of the resultant...

article

Embedding Nano‐Piezoelectrics into Heterointerfaces of S‐Scheme Heterojunctions for Boosting Photocatalysis and Piezophotocatalysis (Small 42/2023)

Shihong Wang, Zengrong Li, Guodong Yang, Yanbo Xu, more

Small > 19 > 42 > n/a - n/a

Embedding Nano‐Piezoelectrics In article number 2302717, Song Bai and co‐workers propose an innovative strategy for better coupling of piezocatalysis and photocatalysis by embedding nano‐piezoelectrics into the heterointerfaces of S‐scheme heterojunction photocatalysts. The embedded piezoelectrics intensify the S‐scheme recombination of weak carriers and accelerate the separation of powerful ones,...

article

Embedding Nano‐Piezoelectrics into Heterointerfaces of S‐Scheme Heterojunctions for Boosting Photocatalysis and Piezophotocatalysis

Shihong Wang, Zengrong Li, Guodong Yang, Yanbo Xu, more

Small > 19 > 42 > n/a - n/a

Step‐scheme (S‐scheme) heterojunctions have exhibited great potential in photocatalysis due to their extraordinary light harvesting and high redox capacities. However, inadequate S‐scheme recombination of useless carriers in weak redox abilities increases the probability of their recombination with useful ones in strong redox capabilities. Herein, a versatile protocol is demonstrated to overcome this...

article

Combined transcriptome and proteome analyses between the cytoplasmic male sterile line and its maintainer line in Welsh onion (Allium fistulosum)

Junxiang Jia, Guodong Yang, Na Li, Xintao Jiang, more

Plant Breeding > 142 > 5 > 690 - 699

Cytoplasmic male sterility (CMS) is dispensable for research of heterosis and investigation of nuclear–cytoplasmic interaction in Welsh onion. The molecular mechanism of the cytoplasmic male sterile line and its maintainer line was investigated by combined transcriptome and proteome analyses in Welsh onion. The 410,585 full‐length non‐chimeric (FLNC, full‐length readsnon‐Chimeric) sequences were obtained,...

article

Manufacture and Mechanical Properties of Batwing‐Type Al Cellular Metamaterials by Selective Laser Melting

Gaoqian Yuan, Qing Zhu, Kezhuo Li, Jingzhe Zhang, more

Advanced Engineering Materials > 25 > 17 > n/a - n/a

Designing metallic cellular structures with triply periodic minimal surfaces (TPMS) is a novel approach for preparing multifunctional and lightweight metamaterials. TPMS‐structured Batwing Al cellular metamaterials are fabricated using selective laser melting. The mechanical performance, failure/deformation modes, and energy absorption capacity of the metamaterials are investigated. It is demonstrated...

article

Tyrosylprotein sulfotransferase suppresses ABA signaling via sulfation of SnRK2.2/2.3/2.6

Jun Wang, Chunyan Wang, Tianrun Wang, Shizhong Zhang, more

Journal of Integrative Plant Biology > 65 > 8 > 1846 - 1851

Phytohormone abscisic acid (ABA) plays vital roles in stress tolerance, while long‐term overactivation of ABA signaling suppresses plant growth and development. However, the braking mechanism of ABA responses is not clear. Protein tyrosine sulfation catalyzed by tyrosylprotein sulfotransferase (TPST) is a critical post‐translational modification. Through genetic screening, we identified a tpst mutant...

article

Regulation of drought tolerance in Arabidopsis involves the PLATZ4‐mediated transcriptional repression of plasma membrane aquaporin PIP2;8

Miao Liu, Chunyan Wang, Zhen Ji, Junyao Lu, more

The Plant Journal > 115 > 2 > 434 - 451

Plant A/T‐rich protein and zinc‐binding protein (PLATZ) transcription factors play important roles in plant growth, development and abiotic stress responses. However, how PLATZ influences plant drought tolerance remains poorly understood. The present study showed that PLATZ4 increased drought tolerance in Arabidopsis thaliana by causing stomatal closure. Transcriptional profiling analysis revealed...

article

Efficient Delivery of GSDMD‐N mRNA by Engineered Extracellular Vesicles Induces Pyroptosis for Enhanced Immunotherapy

Yuqi Xing, Feiyu Zhang, Panpan Ji, Mengying Wei, more

Small > 19 > 20 > n/a - n/a

Pyroptosis is a newly discovered inflammatory form of programmed cell death, which promotes systemic immune response in cancer immunotherapy. GSDMD is one of the key molecules executing pyroptosis, while therapeutical delivery of GSDMD to tumor cells is of great challenge. In this study, an extracellular vesicles‐based GSDMD‐N mRNA delivery system (namely EV^Tx) is developed for enhanced cancer immunotherapy,...

article

Efficient Delivery of GSDMD‐N mRNA by Engineered Extracellular Vesicles Induces Pyroptosis for Enhanced Immunotherapy (Small 20/2023)

Yuqi Xing, Feiyu Zhang, Panpan Ji, Mengying Wei, more

Small > 19 > 20 > n/a - n/a

Engineered Extracellular Vesicles In article number 2204031, Jing Zhao, Guodong Yang, Angang Yang, and co‐workers develop an extracellular vesicle‐based GSDMD‐N mRNA delivery system (EV^Tx), in which GSDMD‐N mRNA is encapsulated inside the vesicle, HER2 antibody is displayed on the surface, and sonosensitizer Ce6 is incorporated into the membrane. When endocytosed by HER2⁺ cancer cells, EV^Tx efficiently...

article

Plasmonic Metal Mediated Charge Transfer in Stacked Core–Shell Semiconductor Heterojunction for Significantly Enhanced CO₂ Photoreduction

Shihong Wang, Yan Zhang, Yiyi Zheng, Yanbo Xu, more

Small > 19 > 2 > n/a - n/a

Construction of core–shell semiconductor heterojunctions and plasmonic metal/semiconductor heterostructures represents two promising routes to improved light harvesting and promoted charge separation, but their photocatalytic activities are respectively limited by sluggish consumption of charge carriers confined in the cores, and contradictory migration directions of plasmon‐induced hot electrons...

article

DEMETHYLATION REGULATOR 1 regulates DNA demethylation of the nuclear and mitochondrial genomes

Zhen Wang, Hao Zheng, Jinguang Huang, Guodong Yang, more

Journal of Integrative Plant Biology > 64 > 12 > 2344 - 2360

Active DNA demethylation effectively modulates gene expression during plant development and in response to stress. However, little is known about the upstream regulatory factors that regulate DNA demethylation. We determined that the demethylation regulator 1 (demr1) mutant exhibits a distinct DNA methylation profile at selected loci queried by methylation‐sensitive polymerase chain reaction and globally...

article

Protein fractionation of pH‐responsive brush‐modified ethylene vinyl alcohol copolymer membranes*

Hui Ye, Yining Zhou, Guodong Yang, Tengfei Yu, more

Polymer Engineering & Science > 62 > 4 > 1041 - 1051

Protein fractionation and purification remain challenging in membrane separation. Herein, a pH‐responsive membrane was developed by grafting the brush‐like poly(dimethylaminoethyl methacrylate) (PDMAEMA) via ATRP onto the ethylene vinyl alcohol copolymer (EVAL) membrane for protein fractionation. The PDMAEMA brushes are distributed in all pore channels of the membrane. Based on the electrostatic and...

article

Emerging Stacked Photocatalyst Design Enables Spatially Separated Ni(OH)₂ Redox Cocatalysts for Overall CO₂ Reduction and H₂O Oxidation

Qian Liu, Shihong Wang, Weihao Mo, Yiyi Zheng, more

Small > 18 > 9 > n/a - n/a

Construction of photocatalytic systems with spatially separated dual cocatalysts is considered as a promising route to modulate charge separation/transfer, promote surface redox reactivities, and prevent unwanted reverse reactions. However, past efforts on the loading of spatially separated double‐cocatalysts are limited to hollow structured semiconductors with inner/outer surface and monocrystalline...

article

Significantly Enhanced Photocatalytic CO₂ Reduction by Surface Amorphization of Cocatalysts

Qin Chen, Weihao Mo, Guodong Yang, Shuxian Zhong, more

Small > 17 > 45 > n/a - n/a

Rational phase engineering of reduction cocatalyst offers a promising route to modulate the photocatalytic activity and selectivity in the conversion of CO₂ to chemical feedstocks. However, it remains a great challenge to choose a suitable phase given that high‐crystallinity phase is more conducive to the charge transfer and separation, while amorphous phase is more favorable for the adsorption and...

article

Function identification of MdTIR1 in apple root growth benefited from the predicted MdPPI network

Lin Liu, Zipeng Yu, Yang Xu, Cheng Guo, more

Journal of Integrative Plant Biology > 63 > 4 > 723 - 739

Protein–protein interaction (PPI) network analysis is an effective method to identify key proteins during plant development, especially in species for which basic molecular research is lacking, such as apple (Malus domestica). Here, an MdPPI network containing 30 806 PPIs was inferred in apple and its quality and reliability were rigorously verified. Subsequently, a root‐growth subnetwork was extracted...

article

Dual roles of the serine/arginine‐rich splicing factor SR45a in promoting and interacting with nuclear cap‐binding complex to modulate the salt‐stress response in Arabidopsis

Ying Li, Qianhuan Guo, Peng Liu, Jinguang Huang, more

New Phytologist > 230 > 2 > 641 - 655

Alternative splicing (AS) is emerging as a critical co‐transcriptional regulation for plants in response to environmental stresses. Although multiple splicing factors have been linked to the salt‐sensitive signaling network, the molecular mechanism remains unclear. We discovered that a conserved serine/arginine‐rich (SR)‐like protein, SR45a, as a component of the spliceosome, was involved in post‐transcriptional...

article

Alterations of Nedd4‐2‐binding capacity in PY‐motif of Na_V1.5 channel underlie long QT syndrome and Brugada syndrome

Ya Wang, Yuan Du, Ling Luo, Peijing Hu, more

Acta Physiologica > 229 > 2 > n/a - n/a

Aims Pathogenic variants of the SCN5A gene can cause Brugada syndrome (BrS) and long QT syndrome (LQTS), which predispose individuals to potentially fatal ventricular arrhythmias and sudden cardiac death. SCN5A encodes the Na_V1.5 protein, the pore forming α‐subunit of the voltage‐dependent cardiac Na⁺ channel. Using a WW domain, the E3 ubiquitin ligase Nedd4‐2 binds to the PY‐motif ([L/P]PxY) within...

article

The Brassicaceae‐specific secreted peptides, STMPs, function in plant growth and pathogen defense

Zipeng Yu, Yang Xu, Lifei Zhu, Lei Zhang, more

Journal of Integrative Plant Biology > 62 > 4 > 403 - 420

Low molecular weight secreted peptides have recently been shown to affect multiple aspects of plant growth, development, and defense responses. Here, we performed stepwise BLAST filtering to identify unannotated peptides from the Arabidopsis thaliana protein database and uncovered a novel secreted peptide family, secreted transmembrane peptides (STMPs). These low molecular weight peptides, which...

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INFONA - science communication portal

Search results for: Guodong Yang

Lysosome‐Targeting Bacterial Outer Membrane Vesicles for Tumor Specific Degradation of PD‐L1 (Small 43/2024)

Lysosome‐Targeting Bacterial Outer Membrane Vesicles for Tumor Specific Degradation of PD‐L1

Laser‐induced self‐propagating synthesis and electromagnetic wave absorption properties of MoAlB powders

Embedding Nano‐Piezoelectrics into Heterointerfaces of S‐Scheme Heterojunctions for Boosting Photocatalysis and Piezophotocatalysis (Small 42/2023)

Embedding Nano‐Piezoelectrics into Heterointerfaces of S‐Scheme Heterojunctions for Boosting Photocatalysis and Piezophotocatalysis

Combined transcriptome and proteome analyses between the cytoplasmic male sterile line and its maintainer line in Welsh onion (Allium fistulosum)

Manufacture and Mechanical Properties of Batwing‐Type Al Cellular Metamaterials by Selective Laser Melting

Tyrosylprotein sulfotransferase suppresses ABA signaling via sulfation of SnRK2.2/2.3/2.6

Regulation of drought tolerance in Arabidopsis involves the PLATZ4‐mediated transcriptional repression of plasma membrane aquaporin PIP2;8

Efficient Delivery of GSDMD‐N mRNA by Engineered Extracellular Vesicles Induces Pyroptosis for Enhanced Immunotherapy

Efficient Delivery of GSDMD‐N mRNA by Engineered Extracellular Vesicles Induces Pyroptosis for Enhanced Immunotherapy (Small 20/2023)

Plasmonic Metal Mediated Charge Transfer in Stacked Core–Shell Semiconductor Heterojunction for Significantly Enhanced CO₂ Photoreduction

DEMETHYLATION REGULATOR 1 regulates DNA demethylation of the nuclear and mitochondrial genomes

Protein fractionation of pH‐responsive brush‐modified ethylene vinyl alcohol copolymer membranes*

Emerging Stacked Photocatalyst Design Enables Spatially Separated Ni(OH)₂ Redox Cocatalysts for Overall CO₂ Reduction and H₂O Oxidation

Significantly Enhanced Photocatalytic CO₂ Reduction by Surface Amorphization of Cocatalysts

Function identification of MdTIR1 in apple root growth benefited from the predicted MdPPI network

Dual roles of the serine/arginine‐rich splicing factor SR45a in promoting and interacting with nuclear cap‐binding complex to modulate the salt‐stress response in Arabidopsis

Alterations of Nedd4‐2‐binding capacity in PY‐motif of Na_V1.5 channel underlie long QT syndrome and Brugada syndrome

The Brassicaceae‐specific secreted peptides, STMPs, function in plant growth and pathogen defense

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