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Background: The production of ϵ germline gene transcripts (Iϵ + /Cϵ + RNA) precedes class switch recombination to IgE and is induced by IL-4 and/or IL-13. Although Iϵ and Cϵ RNA + B cells have been identified within nasal tissue after in vivo allergen exposure, suggesting local germline transcription, whether these were resident or infiltrating B lymphocytes was not clear....
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