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Methane (CH4) is emerging as a candidate of signal molecule recently. However, whether or how CH4 enhances plant adaptation to aluminum (Al)-contaminated environment is still unknown. In this report, the physiological roles and possible molecular mechanisms of CH4 in the modulation of Al toxicity in alfalfa seedlings were characterized. Our results showed that, CH4 pretreatment could alleviate Al-induced...
Background Study of age related macular degeneration (AMD) has been hampered by lack of human models that represent the complexity of the disease. Here we have developed a human in vitro disease model of AMD to investigate the underlying AMD disease mechanisms. Methods Generation of iPSCs from retinal pigment epithelium (RPE) of AMD donors, age-matched normal donors, skin fibroblasts of a dry AMD...
The effects of oxidative stress on levels of calcium ion (Ca 2+ ) in Aspergillus nidulans were measured using strains expressing aequorin in the cytoplasm (Aeq cyt ) and mitochondria (Aeq mt ). When oxidative stress was induced by exposure to 10-mM H 2 O 2 , the mitochondrial calcium response (Ca mt2+ ) was greater...
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