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Integration of genetic and metabolic network holds promise for providing insight into human disease. Coronary artery disease (CAD) is strongly heritable, but the heritability of metabolic compounds has not been evaluated in human metabolic context. Here we performed a genetic-based computational approach within eight sub-cellular networks from Edinburgh Human Metabolic Network to identify significant...
Homeobox genes play important roles in limb development.Backfootis a recently identified mammalian homeobox gene whose temporal and spatial expression pattern during limb development suggests that it is a key component for specifying the identity and structure of the hindlimb. Here we report the chromosomal mapping of theBackfootlocus in human (BFT) and mouse (Bft). Using single-strand conformation...
A high-resolution radiation hybrid map of human chromosome 18 has been developed by testing DNA samples of 92 radiation hybrids (RH) from a previously characterized chromosome 18-specific RH panel. Half of the 159 STS markers were tested on RH DNA amplified by primer extension preamplification. This map includes 20 genes and 95 polymorphic markers, most of which have heterozygosity frequencies greater...
UDP-galactose:ceramide galactosyltransferase (CGT) (EC 2.4.1.62) catalyzes the final step in the synthesis of galactocerebroside, a glycosphingolipid characteristically abundant in myelin. In this report, we describe the isolation of genomic clones spanning the mouse CGT gene. The mouse CGT gene consists of six exons that span a minimum of 70 kb of DNA and that encode a 541 amino acid translation...
A gene for a protein tyrosine phosphatase (PTPase) was isolated from a human fetal brain cDNA library by PCR amplification. Sequence analysis revealed that the PTPase has a single phosphatase catalytic domain located at the C-terminus that includes the highly conserved amino acid domain [I/V]HCXAGXXR[S/T]GX[F/Y] found in all tyrosine phosphatases. Two proline-rich regions located at the N-terminus...
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