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A series of novel benzofuran carboxylic acid derivatives have been designed and synthesized, with their antagonism effect screened on ET-1-induced contraction in the rat thoracic aortic ring. Some target compounds demonstrated significant inhibitory activity, especially benzo[c]thiadiazole and benzo[c]oxadiazole compounds 29 and 30 showed potent inhibition percentage higher than the contrast compound...
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