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Built upon the hypergeometric distribution, the Fisher Exact Test score (FETS) and its variants offer a natural way of quantifying the level of TF binding site (TFBS) motif enrichment, and have been chosen as the objective functions of several widely used discriminant motif discovery methods, such as HOMER and DREME. In spite of its popularity and efficacy, FETS is non-smooth and non-differentiable,...
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