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4β‐(1,3,4‐oxadiazole‐2‐amino‐5‐methyl)‐4‐deoxypodophyllotoxin (OAMDP), a novel podophyllotoxin derivative, has demonstrated potent anti‐tumor activity with significant cytotoxic effect. Here, we report the anti‐proliferative effect of OAMDP, for which OAMDP could suppress the proliferation of HepG2 cells (human hepatoma cell line) in a dose‐ and time‐dependent manner. After treating with OAMDP, cell...
Cytotoxic activity of 5,7‐dimethoxy‐2‐phenyl‐N‐propylquinolin‐4‐amine (DMPPQA) was investigated in human colon cancer cells HCT‐116 and umbilical vein endothelial cell line HUVEC. The IC50 of DMPPQA on HCT‐116 and HUVEC cells were respectively 1.26 and 7.43 µM after 72 h treatment. DMPPQA inhibited the growth of HCT‐116 and HUVEC cells in concentration‐ and time‐dependent manners. Typical morphological...
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