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Artificial neural networks (ANN) and genetic algorithm (GA) were used to optimize sporulation medium components for improving spores concentration in I. lacteus fermentation broth. Single-factor test design was applied to select suitable sporulation medium components and incubation time. Then both response surface methodology (RSM) and artificial neural network (ANN) was applied to explore the optimum...
The nutritional parameters of protease, which is isolated from mao-tofu and identified as Mucor spp, were studied by response surface methodology (RSM). Glucose, soybean protein and KH2PO4 were analyzed by Box-Behnken design for optimizing their concentrations in the medium and the effect of their mutual interaction on protease activity. Glucose and soybean protein were found in influencing the protease...
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