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Biomolecular simulations have traditionally benefited from increases in the processor clock speed and coarse-grain inter-node parallelism on large-scale clusters. With stagnating clock frequencies, the evolutionary path for performance of microprocessors is maintained by virtue of core multiplication. Graphical processing units (GPUs) offer revolutionary performance potential at the cost of increased...
Biomolecular simulations continue to become an increasingly important component of molecular biochemistry and biophysics investigations. Performance improvements in the simulations based on molecular dynamics (MD) codes are widely desired. This is particularly driven by the rapid growth of biological data due to improvements in experimental techniques. Unfortunately, the factors, which allowed past...
We present a reduced order finite element (FE) algorithm suitable for real-time nonlinear simulation of soft tissues. A dynamic FE formulation with explicit time integration is employed. We demonstrate significant computation acceleration by performing the time integration in a low-dimensional generalised basis, generated from a set of a priori training simulations. The key mechanism for the acceleration...
This paper presents a method for constructing a biomechanical breast model which does not require an initial time- and labour-intensive segmentation of the breast tissue. This is achieved by mapping voxel intensity and enhancement levels directly to Youngpsilas modulus values characteristic of the respective tissues. We demonstrate this new method by incorporating it into a biomechanically based registration...
In modern magnetic resonance imaging (MRI), both patients and radiologists are exposed to strong, nonuniform static magnetic fields inside or outside of the scanner, in which the body movement may be able to induce electric currents in tissues which could be possibly harmful. This paper presents theoretical investigations into the spatial distribution of induced E-fields in the human model when moving...
An inverse methodology to assist in the design of radio-frequency (RF) head coils for high field MRI application is described in this work. Free space time-harmonic electromagnetic Green's functions and preemphasized B/sub 1/ field are used to calculate the current density on the coil cylinder. With B/sub 1/ field preemphasized and lowered in the middle of the RF transverse plane, the calculated current...
Based on our previously developed electrical heart model, an electromechanical biventricular model, which couples the electrical property and mechanical property of the heart, was constructed and the right ventricular wall motion and deformation was simulated using this model. The model was developed on the basis of composite material theory and finite element method. The excitation propagation was...
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