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Background
We investigated the survival impact and toxicity of maintenance metronomic chemotherapy in patients with metastatic/recurrent nasopharyngeal carcinoma (met/rec NPC).
Methods
Ninety‐eight patients with met/rec NPC were first salvaged by IV cisplatin‐based chemotherapy and showed nonprogression disease; then maintenance metronomic chemotherapy for at least 12 months was recommended. We...
BackgroundCarotid blowout syndrome is one of the most devastating complications of nasopharyngeal carcinoma (NPC) therapy.
MethodsA retrospective review was conducted from January 2004 to April 2013. Thirty‐one patients with carotid blowout syndrome were enrolled and a case control study was conducted to analyze the risk factors.
ResultsWhen a comparison was made between the carotid blowout syndrome...
BACKGROUND: The objective of this study was to confirm the relation between plasma Epstein‐Barr virus (EBV) DNA (pEBV DNA) load and treatment outcomes after long‐term follow‐up in patients with nasopharyngeal carcinoma (NPC).
METHODS: In total, 210 patients with NPC were enrolled, including 99 previously reported patients and 111 new patients. They prospectively received treatment with induction chemotherapy...
Treatment failure in high risk neuroblastoma is largely due to development of chemoresistance. NF-κB activation is one of the resistance mechanisms for cancer cells to escape from chemotherapy-induced cell-death. TAK1 is an essential component in genotoxic stresses-induced NF-κB activation; however, the role of TAK1 in the development of chemoresistance in neuroblastoma remains unknown. Using a panel...
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