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Infectious disease pandemics/epidemics have been serious concerns worldwide. Simulations for public health interventions are practically helpful in assisting policy makers to make wise decisions to control and mitigate the spread of infectious diseases. In this paper, we present our contact network based simulation model, which is designed to accommodate various “what-if” scenarios under single and...
A hybrid framework integrating Random Forest and Logistic Regression is proposed and implemented for genome-wide epistasis study. The two-stage approach first uses random forest model to capture a pool of epistasis-prone single nucleotide polymorphisms (SNPs), followed by using logistic regression to identify the significant pair-wise epistasis SNPs. We tested the proposed framework on data obtained...
The H1N1 influenza A 2009 pandemic caused a global concern as it has killed more than 18,000 people worldwide so far. Studies that have found cross-neutralizing antibodies between the 1918 and 2009 pandemic flu elicit a basis of pre-existing immunity against the 2009 H1N1 virus in old population. The cross-reactivity occurs due to conserved antigenic epitopes shared between the two pandemic viruses...
Following the availability of whole genome sequence of Mycobacterium tuberculosis (MTB) in public database, the anticipation of its benefits would definitely falls into the contribution towards development of improved vaccine or drug discovery to fight against the fatal disease, tuberculosis (TB). This research aimed to scan the whole genome sequence of MTB by application of bioinformatics approaches...
Genome Wide Association (GWA) studies are powerful tools to identify genes involved in common human diseases, and are becoming increasingly important in genetic epidemiology research. However, the statistical approaches behind GWA studies lack capability in taking into account the possible interactions among genetic markers; and true disease variants may be lost in statistical noise due to high threshold...
Hospital length of stay (LOS) is a widely accepted indicator of hospital activity and performance of clinical care. We have collected and analyzed data on LOS of 4,086 stroke patients discharged from the Singapore General Hospital (SGH) for the duration 2004-2007. We chose to study stroke patients' data because stroke is an important chronic disease which requires significant social support and healthcare...
A contact network is the well representation of heterogeneous contact behaviors within the population. Incorporating contact networks as well as community structures is important in realistic modeling and simulation for the spread of infectious diseases. We developed the ??HPCgen??, a fast and generic generator of contact networks of large urban cities, with the capacity of automating network re-generations...
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