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GSK3β plays an important role in many physiological functions; dysregulated GSK3β is involved in human diseases such as diabetes, cancer, and Alzheimer's disease. This study uses MD simulations to determine the interaction between GSK3β and a peptide derived from GSKIP, a novel GSK3β interacting protein. Results show that GSKIPtide is inlaid in a binding pocket consisting of an α‐helix and an extended...
A shearer designed by coal company's was taken as a project object, rigid-flexible coupled models of the whole shearer were established based on multi-domain modeling and simulation technology, The technical problems about how to calculate the shearer's loads, how to add the loads on the whole shearer and how to set the simulation solver parameters had been discussed. From the simulation results,...
Building an innovative city is the localization and materialization of building an innovation-oriented country and is a complex systematic social project which should have scientific theoretical basis and guidance. With the life cycle theory and the research results of existing innovative cities, we position the development of the innovative city as four stages qualitatively, which is germination,...
The main purpose of this paper is to study the relationship of CPW's structural parameters while the benchmark impedance is 50 Ω, and the CPW of LiTaO3 electro-optical modulator is taken as an example. Conformal mapping theory is used to obtain the numerical relationship of electrode structure, thickness of the substrate and properties parameters, the results show that the little change of electrode...
Life insurance contracts are often very complex financial products which embed interest rate guarantee and other implicit options. Focusing on the With-Profit life insurance policy in China, this paper presents a dynamic model to develop suitable fair valuation techniques for liability of this category contract. Unlike traditional actuarial valuation method, the model captures several essential elements...
This paper proposes a new fragile watermarking algorithm which is mainly applied to binary document image based on the wet paper code. In order to improve embedding capacity and locating tampered area, some work is done base on the prior research of fragile in this paper. First, we dynamically adjust the bits which are embedded into image according to the number of turnover pixels and make the turnover...
Some work is done to improve embedding capacity and locate tampered regions base on the prior research of fragile document watermark in this paper. And an effective fragile document watermarking algorithm is proposed. The wet paper code which adjusts the number of embedding watermark bits dynamically and takes full advantage of turnover pixels is used for embed watermark to improve embedding capacity...
Land surface temperature (LST) is a key parameter of surface physical process. It's a effective way to measure the LST by remote sensing data. But, The radiance leaving the earth-atmosphere system which can be sensed by a satellite borne radiometer is the sum of radiation emission from the earth surface and each atmospheric level that are transmitted to the top of the atmosphere. It can be separated...
We propose an efficient and secure mutual authentication and key exchange protocol suitable for applications using low-power mobile communications. It maintains the required level of security and has the property of perfect forward secrecy which is not possessed by other protocols such as ES-MAKEP, L-MAKEP, and I-MAKEP. Moreover, the paper also provides a formal proof to guarantee the security of...
Rapid progress has been made recently in the understanding of heavy metal sorption and speciation on sediment and soils. One aspect that was overlooked in the previous studies was the process of pollutant transformation and transportation in hyper-concentrated solid-liquid systems. In this paper, batch experiments on copper sorption in association with loess at high sediment concentrations were conducted...
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