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Interferon-α2b (IFN-α2b) and human serum albumin (HSA) fusion protein (IFN-α2b–HSA) is a promising long acting formulation of IFN-α2b for the treatment of hepatitis C. However, accelerated mechanical and thermal stress tests revealed that IFN-α2b–HSA was prone to disulfide-linked aggregation. The formation of aggregates was associated with an increase in immunogenicity in mice. The addition of non-ionic...
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