Search results for: Patrick M Boyle

Items from 1 to 20 out of 26 results

article

Machine learning identifies esophageal luminal temperature patterns associated with thermal injury in catheter ablation for atrial fibrillation

Yaacoub Chahine, Tanzina Afroze, Savannah F. Bifulco, Demyan V. Tekmenzhi, more

Journal of Cardiovascular Electrophysiology > 35 > 4 > 737 - 746

Introduction Luminal esophageal temperature (LET) monitoring during atrial fibrillation (AF) ablation is widely used to reduce the incidence of endoscopically detected esophageal lesion (EDEL). We sought to assess whether specific patterns of LET variation are associated with EDEL. Methods A high‐fidelity multisensor probe was used to record LET in AF patients undergoing radiofrequency ablation...

article

Graft–host coupling changes can lead to engraftment arrhythmia: a computational study

Chelsea E. Gibbs, Silvia Marchianó, Kelly Zhang, Xiulan Yang, more

The Journal of Physiology > 601 > 13 > 2733 - 2749

Abstract After myocardial infarction (MI), a significant portion of heart muscle is replaced with scar tissue, progressively leading to heart failure. Human pluripotent stem cell‐derived cardiomyocytes (hPSC‐CM) offer a promising option for improving cardiac function after MI. However, hPSC‐CM transplantation can lead to engraftment arrhythmia (EA). EA is a transient phenomenon arising shortly after...

article

Elevated fibrosis burden as assessed by MRI predicts cryoballoon ablation failure

Patrick M. Boyle, Sakher Sarairah, Kirsten T. Kwan, Griffin D. Scott, more

Journal of Cardiovascular Electrophysiology > 34 > 2 > 302 - 312

Introduction Late‐gadolinium enhancement magnetic resonance (LGE‐MRI) imaging is increasingly used in management of atrial fibrillation (AFib) patients. Here, we assess the usefulness of LGE‐MRI‐based fibrosis quantification to predict arrhythmia recurrence in patients undergoing cryoballoon ablation. Our secondary goal was to compare two widely used fibrosis quantification methods. Methods In...

article

Dynamic voltage threshold adjusted substrate modification technique for complex atypical atrial flutters with varying circuits

Nilubon Methachittiphan, Nazem Akoum, Rakesh Gopinathannair, Patrick M Boyle, more

Pacing and Clinical Electrophysiology > 43 > 11 > 1273 - 1280

Background Atypical atrial flutter (AFL) is common in patients with postsurgical atrial scar, with macro‐ or microscopic channels in the scar acting as substrate for reentry. Heterogeneous atrial scarring can cause varying flutter circuits, which makes mapping and ablation challenging, and recurrences common. Aim We hypothesize that dynamically adjusting voltage thresholds can identify heterogeneous...

article

Computational Identification of Ventricular Arrhythmia Risk in Pediatric Myocarditis

Mark J. Cartoski, Plamen P. Nikolov, Adityo Prakosa, Patrick M. Boyle, more

Pediatric Cardiology > 2019 > 40 > 4 > 857-864

Children with myocarditis have increased risk of ventricular tachycardia (VT) due to myocardial inflammation and remodeling. There is currently no accepted method for VT risk stratification in this population. We hypothesized that personalized models developed from cardiac late gadolinium enhancement magnetic resonance imaging (LGE-MRI) could determine VT risk in patients with myocarditis using a...

article

Termination of re‐entrant atrial tachycardia via optogenetic stimulation with optimized spatial targeting: insights from computational models

Patrick M. Boyle, Michael J. Murphy, Thomas V. Karathanos, Sohail Zahid, more

The Journal of Physiology > 596 > 2 > 181 - 196

Key points Optogenetics has emerged as a potential alternative to electrotherapy for treating heart rhythm disorders, but its applicability for terminating atrial arrhythmias remains largely unexplored. We used computational models reconstructed from clinical MRI scans of fibrotic patient atria to explore the feasibility of optogenetic termination of atrial tachycardia (AT), comparing two different...

article

Opsin spectral sensitivity determines the effectiveness of optogenetic termination of ventricular fibrillation in the human heart: a simulation study

Thomas V. Karathanos, Jason D. Bayer, Dafang Wang, Patrick M. Boyle, more

The Journal of Physiology > 594 > 23 > 6879 - 6891

Key points Optogenetics‐based defibrillation, a theoretical alternative to electrotherapy, involves expression of light‐sensitive ion channels in the heart (via gene or cell therapy) and illumination of the cardiac surfaces (via implanted LED arrays) to elicit light‐induced activations. We used a biophysically detailed human ventricular model to determine whether such a therapy could terminate fibrillation...

article

Feasibility of using patient-specific models and the “minimum cut” algorithm to predict optimal ablation targets for left atrial flutter

Sohail Zahid, Kaitlyn N. Whyte, Erica L. Schwarz, Robert C. Blake, more

Heart Rhythm > 2016 > 13 > 8 > 1687-1698

Left atrial flutter (LAFL) occurs in patients after atrial fibrillation ablation. Identification of optimal ablation targets to terminate LAFL remains challenging.The purpose of this study was to use patient-specific models to simulate LAFL and predict optimal ablation targets using a novel approach based on flow network theory.Late gadolinium-enhanced cardiac magnetic resonance scans from 10 patients...

article

Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia

Hermenegild J. Arevalo, Patrick M. Boyle, Natalia A. Trayanova

Progress in Biophysics and Molecular Biology > 2016 > 121 > 2 > 185-194

Current understanding of cardiac electrophysiology has been greatly aided by computational work performed using rabbit ventricular models. This article reviews the contributions of multiscale models of rabbit ventricles in understanding cardiac arrhythmia mechanisms. This review will provide an overview of multiscale modeling of the rabbit ventricles. It will then highlight works that provide insights...

chapter

The Purkinje System and Cardiac Geometry: Assessing Their Influence on the Paced Heart

Daniel Romero, Rafael Sebastian, Bart H. Bijnens, Viviana Zimmerman, more

Lecture Notes in Computer Science > Functional Imaging and Modeling of the Heart > Cardiac Architecture Imaging and Analysis > 68-77

Whole heart computer models are being widely used to assess treatment planning like Cardiac Resynchronization Therapy (CRT), a recognized treatment for heart failure. Certain aspects like cardiac geometry and the Purkinje system (PS) are still sometimes neglected on the studies. The present study includes a model of the human ventricles with incorporated anatomical structures such as myofibers orientation...

article

Pulse Duration Determines Efficacy of Arrhythmia Termination via Targeted Optogenetic Stimulation

Patrick M. Boyle, Michael Murphy, Thomas V. Karathanos, Dafang Wang, more

Biophysical Journal > 2016 > 110 > 3 Supplement 1 > 585a

article

Somatic Mosaicism of Novel SCN5A Mutation in Purkinje System (PS) may Underlie 2:1 Block in an Infant with Long QT Syndrome (LQTS)

Joseph K. Yu, Patrick M. Boyle, Thomas O'Hara, James R. Priest, more

Biophysical Journal > 2016 > 110 > 3 Supplement 1 > 527a

article

Corrigendum to: Computational modeling of cardiac optogenetics: Methodology overview & review of findings from simulations [Comput. Biol. Med. 65C (2015) 200–208]

Patrick M. Boyle, Thomas V. Karathanos, Emilia Entcheva, Natalia A. Trayanova

Computers in Biology and Medicine > 2015 > 67 > C > 184

article

Computational modeling of cardiac optogenetics: Methodology overview & review of findings from simulations

Patrick M. Boyle, Thomas V. Karathanos, Emilia Entcheva, Natalia A. Trayanova

Computers in Biology and Medicine > 2015 > 65 > Complete > 200-208

Cardiac optogenetics is emerging as an exciting new potential avenue to enable spatiotemporally precise control of excitable cells and tissue in the heart with low-energy optical stimuli. This approach involves the expression of exogenous light-sensitive proteins (opsins) in target heart tissue via viral gene or cell delivery. Preliminary experiments in optogenetically-modified cells, tissue, and...

article

“Beauty is a light in the heart”: The transformative potential of optogenetics for clinical applications in cardiovascular medicine1

Patrick M. Boyle, Thomas V. Karathanos, Natalia A. Trayanova

Trends in Cardiovascular Medicine > 2015 > 25 > 2 > 73-81

Optogenetics is an exciting new technology in which viral gene or cell delivery is used to inscribe light sensitivity in excitable tissue to enable optical control of bioelectric behavior. Initial progress in the fledgling domain of cardiac optogenetics has included in vitro expression of various light-sensitive proteins in cell monolayers and transgenic animals to demonstrate an array of potentially...

article

Opsin Spectral Sensitivity Determines the Effectiveness of Optogenetics-Based Defibrillation

Thomas V. Karathanos, Patrick M. Boyle, Jason D. Bayer, Dafang Wang, more

Biophysical Journal > 2015 > 108 > 2 Supplement 1 > 148a

article

Transmural IK(ATP) heterogeneity as a determinant of activation rate gradient during early ventricular fibrillation: Mechanistic insights from rabbit ventricular models

Patrick M. Boyle, Stéphane Massé, Kumaraswamy Nanthakumar, Edward J. Vigmond

Heart Rhythm > 2013 > 10 > 11 > 1710-1717

Activation rate (AR) gradients develop during ventricular fibrillation (VF), with the highest AR on the surface near Purkinje system (PS) terminals (endocardium in humans and rabbits and epicardium in pigs). The application of glibenclamide to block adenosine triphosphate (ATP)-sensitive potassium current (I _K(ATP) ) before VF induction eliminates transmural AR gradients and prevents the induction...

article

Fusion during entrainment of orthodromic reciprocating tachycardia is enhanced for basal pacing sites but diminished when pacing near Purkinje system end points

Patrick M. Boyle, George D. Veenhuyzen, Edward J. Vigmond

Heart Rhythm > 2013 > 10 > 3 > 444-451

In the electrophysiological laboratory, orthodromic atrioventricular reciprocating tachycardia (ORT) can be distinguished from atrial tachycardia and atrioventricular node reentry tachycardia by identifying orthodromic and antidromic wavefront fusion during ventricular overdrive pacing (VOP). Previous work has shown that basal VOP near the accessory pathway (AP) increases the likelihood of observing...

article

A BioBrick compatible strategy for genetic modification of plants

Patrick M Boyle, Devin R Burrill, Mara C Inniss, Christina M Agapakis, more

Journal of Biological Engineering > 2012 > 6 > 1 > 1-8

Background Plant biotechnology can be leveraged to produce food, fuel, medicine, and materials. Standardized methods advocated by the synthetic biology community can accelerate the plant design cycle, ultimately making plant engineering more widely accessible to bioengineers who can contribute diverse creative input to the design process. Results This paper presents work done largely by undergraduate...

article

Parts plus pipes: Synthetic biology approaches to metabolic engineering

Patrick M. Boyle, Pamela A. Silver

Metabolic Engineering > 2012 > 14 > 3 > 223-232

Synthetic biologists combine modular biological “parts” to create higher-order devices. Metabolic engineers construct biological “pipes” by optimizing the microbial conversion of basic substrates to desired compounds. Many scientists work at the intersection of these two philosophies, employing synthetic devices to enhance metabolic engineering efforts. These integrated approaches promise to do more...

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INFONA - science communication portal

Search results for: Patrick M Boyle

Machine learning identifies esophageal luminal temperature patterns associated with thermal injury in catheter ablation for atrial fibrillation

Graft–host coupling changes can lead to engraftment arrhythmia: a computational study

Elevated fibrosis burden as assessed by MRI predicts cryoballoon ablation failure

Dynamic voltage threshold adjusted substrate modification technique for complex atypical atrial flutters with varying circuits

Computational Identification of Ventricular Arrhythmia Risk in Pediatric Myocarditis

Termination of re‐entrant atrial tachycardia via optogenetic stimulation with optimized spatial targeting: insights from computational models

Opsin spectral sensitivity determines the effectiveness of optogenetic termination of ventricular fibrillation in the human heart: a simulation study

Feasibility of using patient-specific models and the “minimum cut” algorithm to predict optimal ablation targets for left atrial flutter

Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia

The Purkinje System and Cardiac Geometry: Assessing Their Influence on the Paced Heart

Pulse Duration Determines Efficacy of Arrhythmia Termination via Targeted Optogenetic Stimulation

Somatic Mosaicism of Novel SCN5A Mutation in Purkinje System (PS) may Underlie 2:1 Block in an Infant with Long QT Syndrome (LQTS)

Corrigendum to: Computational modeling of cardiac optogenetics: Methodology overview & review of findings from simulations [Comput. Biol. Med. 65C (2015) 200–208]

Computational modeling of cardiac optogenetics: Methodology overview & review of findings from simulations

“Beauty is a light in the heart”: The transformative potential of optogenetics for clinical applications in cardiovascular medicine1

Opsin Spectral Sensitivity Determines the Effectiveness of Optogenetics-Based Defibrillation

Transmural IK(ATP) heterogeneity as a determinant of activation rate gradient during early ventricular fibrillation: Mechanistic insights from rabbit ventricular models

Fusion during entrainment of orthodromic reciprocating tachycardia is enhanced for basal pacing sites but diminished when pacing near Purkinje system end points

A BioBrick compatible strategy for genetic modification of plants

Parts plus pipes: Synthetic biology approaches to metabolic engineering

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