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Treatment of coronary in-stent restenosis (ISR) is hampered by a high incidence of recurrent ISR. Colchicine is an old drug with known anti-inflammatory and antiproliferative actions. We evaluated the strategy of colchicine combined with conventional balloon angioplasty for the treatment of ISR.Sixty coronary arteries of 60 mini-pigs underwent oversized bare-metal stent implantation to induce ISR...
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