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Fibroblasts promote the angiogenic response of the rat aorta and stabilize microvessels formed by endothelial cells in collagen gels (Villaschi and Nicosia, Lab. Invest. 71:291-299, 1994). To investigate the mechanisms regulating these processes, rat aortic endothelial cells (RAEC) were co-cultured with rat or human fibroblasts in serum-free medium. When physical contact between the two cell types...
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