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Technological innovations in continuous-flow microfluidics require updated automated synthesis methods. As new microfluidic components and biochemical applications are constantly introduced, the current functionality-based application mapping methods and the fixed-time-slot scheduling methods are insufficient to solve the new design challenges. In this work, we propose a component-oriented general...
Microfluidic biochips are being used to perform ever more complex and error-prone bioassays. This results in increasing demand for design automation for such biochips, as these sophisticated designs are beyond the scope of manual design. So far, much research in the field of design automation has been devoted to satisfy this demand from biology, but the gap between design automation and biology is...
Continuous-flow microfluidics have evolved rapidly in the last decades, due to their advantages in effective and accurate control. However, complex control results in complicated valve actuations. As a result, sophisticated interactions between control and flow layers substantially raise the design difficulty. Previous work on design automation for microfluidics neglects the interactions between the...
Microfluidic biochip technology integrates miniaturized components into a chip that can perform traditional biochemical laboratory procedures. Commercial impact is highlighted by the recent acquisition of Advanced Liquid Logic by Illumina Inc., a leader in DNA sequencing and biomolecular analysis. Due to the inherent variability involved in many biochemical processes, uncertainties manifest themselves...
In recent years, digital microfluidic (DMF) biochips have become the most popular and emerging technology for implementing a wide range of biochemical laboratory protocols on a small hand-held device. Due to its high-throughput, high-sensitivity, automatic control, and low cost, DMF biochips are now being considered for several real-life applications like on-chip diagnosis of various cardiovascular...
Recently, digital microfluidic biochips (DMFBs) have revolutionized many biochemical laboratory procedures and received much attention due to their many advantages, such as high throughput, automatic control, and low cost. To meet the challenges of increasing design complexity, computer-aided-design (CAD) tools have been used to build DMFBs efficiently. Current CAD tools generally conduct a two-stage...
The 2010 International Technology Roadmap for Semiconductors (ITRS) predicted that bio-medical chips will soon revolutionize the healthcare market. These bio-medical chips should be able to sense and actuate, store and manipulate data, and transmit information. To realize such bio-medical chips, the integration of embedded systems and microfluidics inevitably leads to a new research dimension for...
Microfluidic biochips are replacing the conventional biochemical analyzers, and are able to integrate on-chip all the basic functions for biochemical analysis. The “digital” microfluidic biochips (DM-FBs) are manipulating liquids not as a continuous flow, but as discrete droplets on a two-dimensional array of electrodes. Basic mi-crofluidic operations, such as mixing and dilution, are performed on...
Advances in droplet-based digital microfluidics have led to the emergence of biochips for automating laboratory procedures in biochemistry and molecular biology. These devices enable the precise control of microliter of nanoliter volumes of biochemical samples and reagents. They combine electronics with biology, and integrate various bioassay operations, such as sample preparation, analysis, separation,...
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