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Alveolar rhabdomyosarcoma frequently exhibit specific translocations resulting in the fusion of the FKHR gene at 13q14 with either the PAX3 gene at 2q35 or, more rarely, the PAX7 gene 1p36. Comparative genomic hybridization revealed amplification at 13q14 and 1p36, suggesting amplification of the PAX7-FKHR fusion gene in two cases of alveolar rhabdomyosarcoma. A PAX7-FKHR fusion transcript was demonstrated...
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