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BackgroundPathogen reduction technologies (PRTs) can induce platelet (PLT) lesions that reduce PLT survival and recovery from circulation and may be associated with acute lung injury (ALI).
Study Design and MethodsHuman PLTs (hPLTs) in plasma with or without single or multiple Mirasol PRT treatments were assessed in vitro by aggregation and percentage of P‐selectin expression. In vivo studies included...
BACKGROUND: We recently reported that infusion of ultraviolet light B (UVB)‐exposed human platelets (HPs) can be the second event that mediates acute lung injury (ALI) in a two‐event mouse model of transfusion‐related acute lung injury (mTRALI). We have now identified changes in HPs induced by UVB light and responses of the recipient animal that mediate the mTRALI.
STUDY DESIGN AND METHODS: Effects...
BACKGROUND: Ultraviolet B (UVB) light has been used alone on platelet (PLT) transfusion products to prevent alloimmunization or with chemical sensitizers to reduce pathogens. Such processing can damage PLTs and potentiate their storage lesion. Transfusion‐related acute lung injury (ALI) has occurred in patients whose underlying condition led to an inflamed endothelium and who were transfused with...
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