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Synapse formation in complex neuronal network is a pivotal process for normal functioning of nervous system. Although intense research has been conducted, how neurons and axons are guided toward the target remains largely unclear. In traditional opinions, axons are directed through chemotaxis, while recently mechanotaxis has been brought up as a potential complementary mechanism, as it can provide...
Axon Pathfinding
In article number 2301926, Qihui Fan, Fangfu Ye, and co‐workers show that the mechanical signals transmitted through the fibrous extracellular matrix enable precise guidance of axons and neuronal cells towards target neurites, leading to highly efficient neural network formation. This precise axon guidance mechanism is associated with the activation of mechanosensitive ion channels,...
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