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Auto-regulatory transcriptional feedback, where the protein expressed from a gene inhibits its own transcription, is known to reduce stochastic fluctuations in protein numbers. Work has demonstrated the existence of negative feedback loops not only at the transcriptional level but also at the translational level. We investigate the noise suppression abilities of feedback loops at the translational...
Auto-regulatory negative feedback loops, where the protein expressed from a gene inhibits its own expression are common gene network motifs within cells. We investigate when will introducing a negative feedback mechanism be beneficial in terms of increasing a fitness function that is given by the probability of maintaining protein numbers above a critical threshold. Our results show the existence...
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