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Objective
Mesiodens is the most common type of supernumerary tooth which includes a population prevalence of 0.15%–1.9%. Alongside evidence that the condition is heritable, mutations in single genes have been reported in few human supernumerary tooth cases. Gene sequencing methods in tradition way are time‐consuming and labor‐intensive, whereas next‐generation sequencing and bioinformatics are cost‐effective...
Objectives
Our study aims to identify genetic variants associated with hereditary gingival fibromatosis (HGF) by applying whole‐exome sequencing (WES) and bioinformatics analyses such as gene set enrichment analysis (GSEA) and protein functional network study.
Subjects and Methods
Two affected siblings whose grandparents and parents have normal gingiva were chosen for our investigation. Saliva...
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