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Regulation of sizes and shapes of tooth are important matters to consider in generating an entirely bioengineered tooth for future tooth replacement therapy. In our current study, we investigated that whether an extent of contact area between epithelial and mesenchymal cell aggregates, which was reconstituted from embryonic day 14.5 molar tooth germ-derived single cells by our cell manipulation method,...
The regenerative therapy ultimately aims to develop bioengineered organs that can replace lost or damaged organs following disease, injury or aging. Recently, we showed that the artificial organ germ, which generates a structurally correct tooth, could be reconstituted by in vitro cell manipulation (Nature Methods 4, 227-230, 2007). In this study, we revealed that neural crest-like cells, which were...
In order to survive in complex natural environments, living organisms have been genetically acquiring various algorithms. Paramecium, for example, exhibits an avoiding reaction when it senses repellent chemicals on the anterior part of the cell. Also, on sensing attractants, it accelerates its swimming velocity and remains in the area. Such a chemotactic response is called chemotaxis. In this paper,...
The nematode Caenorhabditis elegans (C elegans), a relatively simple organism in structure, is one of the most well-studied multicellular organisms. In this study, we develop a virtual C. elegans based on the actual nematode to analyze motor control which uses neuronal circuits and muscles. Although C. elegans processes many kinds of external stimuli, we focus on gentle touch stimulation. Virtual...
This paper focuses on the nematode C. elegans which has a relatively simple structure, and is one of the most analyzed organisms among multicellular ones. We aim to develop a mathematical model of this organism to analyze control mechanisms with respect to locomotion. First, a new motor control model of the C. elegans is proposed, which includes both of the neuronal circuit model and the dynamic model...
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