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Prolongation of action potential duration (APD) and altered calcium (Ca2+) handling in ventricular myocytes are commonly observed in heart failure (HF). This study describes a mathematical model of human HF, using a modified version of the Grandi et al. formulation for human ventricular action potential, which includes the late Na+ current (INaL). A sensitivity analysis is performed to investigate...
Long QT syndrome is a repolarization disorder characterized by marked prolongation of QT interval. A clear consequence of long QT syndrome is the occurrence of a polymorphic ventricular tachycardia called Torsade de Pointes, which has been related to early after depolarizations (EADs) formation. This repolarizing disorder has been observed under pathological situations, such as heart failure, oxidative...
Experimental studies of pro-arrhythmic mechanisms are scarcely performed in humans due to the limited availability of human cardiomyocytes. Subsequently, extrapolation of animal experimental research to humans is widely extended. Our aim is to systematically compare the ionic mechanisms of the main cellular biomarkers of arrhythmic risk between human and rabbit using computer simulations. For this...
The prolongation of action potential duration (APD) is usually related to conditions of low repolarization reserve and leads to long QT syndrome. In these situations, an unbalance between currents can fire early after depolarizations (EADs). This repolarizing disorder has been observed in heart failure situations, where the late sodium current (INaL) has an important role. In this work we evaluate...
The safety factor (SF) is an indicator of the safeness of electrical conduction in the myocardium. In the present work, the estimation of the SF based on the formulation proposed by Shaw and Rudy (1997) has been extended to 2D (SF-2D) and evaluated. Furthermore, the effect of the increment of extracellular potassium concentration ([K+]o) on the SF-2D of a convex wavefront has also been studied and...
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