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G-Protein coupled receptors (GPCRs) constitute the largest group of membrane receptors with great pharmacological interest. The signal transduction within cells is leaded by a wide range of native ligands interact and activate GPCRs. Most of these responses are mediated through the interaction of GPCRs with coupling GTP-binding proteins (G-proteins). For the reason of the information explosion in...
Membrane protein interactions are involved in the regulation and execution of all biochemical pathways within the cell. It is crucial to identify the binding partners for understanding the function of an uncharacterized protein, and when these partners turn out to have known function, deductions about the potential role of the uncharacterized protein can often be made. However, the analysis of interactions...
G-protein-coupled receptors (GPCRs), the largest family of cell surface receptors play an important role in production of therapeutic drugs. However, the functions of many of GPCRs are unknown. Hence we develop an new method for classifying the family of GPCRs. It is difficult to predict the classification of GPCRs by means of conventional sequence alignment approaches because of their highly divergent...
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