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G‐quadruplexes (G4s) have been revived as promising therapeutic targets with the development of immunotherapy, but the G4‐mediated immune response remains unclear. We designed a novel class of G4‐binding organic‐platinum hybrids, L1‐cispt and L1‐transpt, with spatial matching for G4 binding and G4 DNA reactivity for binding site locking. The solution structure of L1‐transpt‐MYT1L G4 demonstrated the...
G‐quadruplexes (G4s) have been revived as promising therapeutic targets with the development of immunotherapy, but the G4‐mediated immune response remains unclear. We designed a novel class of G4‐binding organic‐platinum hybrids, L1‐cispt and L1‐transpt, with spatial matching for G4 binding and G4 DNA reactivity for binding site locking. The solution structure of L1‐transpt‐MYT1L G4 demonstrated the...
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