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Sepsis, a critical bacterial infection of the bloodstream, is a serious cause of illness in neonatal period in both premature and at term newborns. It is important to look for parameters that can help earlier detection of sepsis in the newborn. Previous studies have shown that Heart Rate Variability is reduced when associated with sepsis and diminish the adaptive capacity of the individual, degrading...
Prolongation of action potential duration (APD) and altered calcium (Ca2+) handling in ventricular myocytes are commonly observed in heart failure (HF). This study describes a mathematical model of human HF, using a modified version of the Grandi et al. formulation for human ventricular action potential, which includes the late Na+ current (INaL). A sensitivity analysis is performed to investigate...
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