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The safety factor (SF) is an indicator of the safeness of electrical conduction in the myocardium. In the present work, the estimation of the SF based on the formulation proposed by Shaw and Rudy (1997) has been extended to 2D (SF-2D) and evaluated. Furthermore, the effect of the increment of extracellular potassium concentration ([K+]o) on the SF-2D of a convex wavefront has also been studied and...
The safety factor (SF) is an indicator of the safeness of electrical conduction in the myocardium. In the present work, we have studied the sensitivity of the SF defined by Shaw and Rudy to the integration interval (II) using computer simulations, and then defined and evaluated a new and simplified method to calculate SF (SFm). Our results reveal that the sensitivity of the SF to the II is negligible...
In this work, we have studied the changes that acute myocardial ischemia exerts in our formulation of the safety factor of conduction (SFm) which consists on a modification of the SF proposed by Shaw and Rudy. Specifically, the effect of each component of ischemia (hyperkalemia, hypoxia and acidosis) was studied separately, and also the evolution of the SFm after the onset of ischemia was obtained...
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