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Presenilin 1 (PS1), a causative molecule of familial Alzheimer's disease (AD), is known to be an unprimed substrate of glycogen synthase kinase 3 β (GSK3β) [Twomey and McCarthy (2006) FEBS Lett 580:4015–4020] and is phosphorylated at serine 353, 357 residues in its cytoplasmic loop region [Kirschenbaum et al. (2001) J Biol Chem 276:7366–7375]. In this report, we investigated the effect of PS1 phosphorylation...
Dysfunction in the synapse is recognized as an early and the primary pathological process in Alzheimer’s disease (AD). N-cadherin, an essential adhesion molecule for excitatory synaptic contact, forms a complex with presenilin 1 (PS1) and β-catenin in the synaptic membrane. N-cadherin is sequentially cleaved by ADAM10 and PS1/γ-secretase, producing a cytoplasmic fragment, N-cadherin C-terminal fragment...
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