Search results for: Lichuan Liu

Items from 1 to 20 out of 43 results

article

Rhodium‐Catalyzed Intermolecular Silylation of C_sp−H by Silacyclobutanes

Tao He, Bin Li, Lichuan Liu, Wenpeng Ma, more

Chemistry – A European Journal > 27 > 18 > 5648 - 5652

The signature reactivity of silacyclobutane (SCB) is their cycloaddition reactions with various π bonds. Recently, the first cases were disclosed where SCBs reacted with both C_sp2−H and C_sp3−H σ bonds in an intramolecular fashion. Herein, it is reported that SCB is also an efficient reagent for C_sp−H bond silylation. Thus, rhodium‐catalyzed intermolecular reactions between SCBs and terminal alkynes...

article

Assessment of OATP transporter‐mediated drug–drug interaction using physiologically‐based pharmacokinetic (PBPK) modeling – a case example

Yuan Chen, Rui Zhu, Fang Ma, Jialin Mao, more

Biopharmaceutics & Drug Disposition > 39 > 9 > 420 - 430

GDC‐0810 was under development as an oral anti‐cancer drug for the treatment of estrogen receptor‐positive breast cancer as a single agent or in combination. In vitro data indicated that GDC‐0810 is a potent inhibitor of OATP1B1/1B3. To assess clinical risk, a PBPK model was developed to predict the transporter drug–drug interaction (tDDI) between GDC‐0810 and pravastatin in human. The PBPK model...

article

Correction to: Application of a Novel ‘Make and Test in Parallel’ Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects

Sravanthi Cheeti, Hao Helen Hou, Eric Nelson, Helen Walker, more

Pharmaceutical Research > 2018 > 35 > 12 > 1-1

The Publisher regrets the typesetting mistake of retaining incorrect text in the Figure 1 caption. The correct text for the caption is “Molecular Structure of GDC-0810 NMG Salt”. The original article has been corrected.

article

Application of a Novel ‘Make and Test in Parallel’ Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects

Sravanthi Cheeti, Hao Helen Hou, Eric Nelson, Helen Walker, more

Pharmaceutical Research > 2018 > 35 > 12 > 1-11

Purpose GDC-0810, administered orally, was used in Phase I and II clinical studies to treat estrogen receptor positive breast cancers. It contains N-methyl-D-glucamine (NMG) salt of GDC-0810 with 10% sodium lauryl sulfate (SLS) as a surfactant and 15% sodium bicarbonate (NaHCO₃) as an alkalizing agent to aid dissolution. To improve the processability of the formulation and reduce potential mucosal...

article

Effect of OATP1B1/1B3 Inhibitor GDC‐0810 on the Pharmacokinetics of Pravastatin and Coproporphyrin I/III in Healthy Female Subjects

Lichuan Liu, Sravanthi Cheeti, Kenta Yoshida, Edna Choo, more

The Journal of Clinical Pharmacology > 58 > 11 > 1427 - 1435

Developed as an oral anticancer drug to treat estrogen receptor–positive breast cancer, GDC‐0810 was shown to be a potent inhibitor of organic anion‐transporting polypeptide 1B1 and 1B3 (OATP1B1/1B3) from an in vitro assay. A clinical study was conducted to assess the drug‐drug interaction potential between GDC‐0810 and pravastatin, which is a relatively selective and sensitive OATP1B1/1B3 substrate...

article

Effect of Microenvironmental pH Modulation on the Dissolution Rate and Oral Absorption of the Salt of a Weak Acid – Case Study of GDC-0810

Hao Helen Hou, Wei Jia, Lichuan Liu, Sravanthi Cheeti, more

Pharmaceutical Research > 2018 > 35 > 2 > 1-11

Purpose The purpose of this work is to investigate the effect of microenvironmental pH modulation on the in vitro dissolution rate and oral absorption of GDC-0810, an oral anti-cancer drug, in human. Methods The pH-solubility profile of GDC-0810 free acid and pH_max of its N-Methyl-D-glucamine (NMG) salt were determined. Precipitation studies were conducted for GDC-0810 NMG salt at different pH values...

chapter

Wireless communication integrated hybrid active noise control system for infant incubators

Lichuan Liu, Lilin Du, Ajit Kolla

2016 IEEE Signal Processing in Medicine and Biology Symposium (SPMB) > 1 - 6

2016 IEEE Signal Processing in Medicine and Biology Symposium (SPMB)

This paper proposed a wireless communication integrated hybrid active noise control (ANC) system that will reduce the level of noise in an infant incubator at the infant's ear and provide two-way wireless communication between infant and his/her parents/caregivers both inside and outside the Neonatal intensive care unit (NICU). The proposed system use ANC technique to reduce the noise. The wireless...

article

Best practices for the use of itraconazole as a replacement for ketoconazole in drug–drug interaction studies

Lichuan Liu, Akintunde Bello, Mark J. Dresser, Donald Heald, more

The Journal of Clinical Pharmacology > 56 > 2 > 143 - 151

Ketoconazole has been widely used as a strong cytochrome P450 (CYP) 3A (CYP3A) inhibitor in drug–drug interaction (DDI) studies. However, the US Food and Drug Administration has recommended limiting the use of ketoconazole to cases in which no alternative therapies exist, and the European Medicines Agency has recommended the suspension of its marketing authorizations because of the potential for serious...

article

Discovery of highly potent and selective Bruton’s tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability

Wendy B. Young, James Barbosa, Peter Blomgren, Meire C. Bremer, more

Bioorganic & Medicinal Chemistry Letters > 2016 > 26 > 2 > 575-579

BTK inhibitor GDC-0834 (1) was found to be rapidly metabolized in human studies, resulting in a suspension of clinical trials. The primary route of metabolism was through cleavage of the acyclic amide bond connecting the terminal tetrahydrobenzothiophene with the central linker aryl ring. SAR studies were focused on reducing metabolic cleavage of this amide, and resulted in the identification of several...

chapter

Multi-channel ANC system using optimized reference microphones based on time difference of arrival

Satoru Hase, Yoshinobu Kajikawa, Lichuan Liu, Sen M. Kuo

2015 23rd European Signal Processing Conference (EUSIPCO) > 305 - 309

2015 23rd European Signal Processing Conference (EUSIPCO)

Feedforward active noise control (ANC) system using upstream reference signal can reduce various noises such as broadband noise by arranging a reference microphone close to a noise source. However, the performance of ANC system deteriorates if the noise environment such as the arrival direction is changed. This is because of the causality constraint that the unwanted noise propagates to the control...

article

Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834

Wendy B. Young, James Barbosa, Peter Blomgren, Meire C. Bremer, more

Bioorganic & Medicinal Chemistry Letters > 2015 > 25 > 6 > 1333-1337

SAR studies focused on improving the pharmacokinetic (PK) properties of the previously reported potent and selective Btk inhibitor CGI-1746 (1) resulted in the clinical candidate GDC-0834 (2), which retained the potency and selectivity of CGI-1746, but with much improved PK in preclinical animal models. Structure based design efforts drove this work as modifications to 1 were investigated at both...

chapter

Hybrid Localization Algorithm in Wireless Sensor Networks and ITS Application in Building Monitoring

Lichuan Liu, Geetha Mavidi

2014 IIAI 3rd International Conference on Advanced Applied Informatics > 97 - 102

2014 IIAI 3rd International Conference on Advanced Applied Informatics (IIAIAAI)

Localization, the determination of geographical location of sensors is a fundamental problem in wireless sensor networks. In this paper we consider a static wireless network in which the reference nodes are static-non moving. We propose a positioning method known as hybrid optimizing algorithm (HOA) which combines steepest decent method and Taylor series expansion method. The steepest decent method...

chapter

Structural differentiation of common bacteria using impedance spectroscopy

Martin Kocanda, Stewart Lipton, Shawn Oppegard, Sherine F. Elsawa, more

IEEE International Conference on Electro/Information Technology > 518 - 523

2014 IEEE International Conference on Electro/Information Technology (EIT)

Microbiological impedance spectroscopy has been employed for several decades to determine the presence and concentration of known bacteria and pathogens. Recent interest in lab-on-a-chip technology has been the motivation to develop miniature, accurate and rapid instrumentation to identify various strains of bacteria thus minimizing the necessity to culture, stain and perform population counting in...

chapter

Novel route towards large scale synthesis of bright, water dispersible core-shell fluorescent dye doped organosilicate nanoparticles

Matthew Marshalek, Shannon K. Boi, Lichuan Liu, Martin Kocanda, more

IEEE International Conference on Electro/Information Technology > 562 - 566

2014 IEEE International Conference on Electro/Information Technology (EIT)

Development of stable, biocompatible and ultra-bright fluorescence agents can lead to highly sensitive and non-invasive tools to locate and monitor biological targets within complex systems, including the human body. The motivation of this research is to have an easily scalable method of synthesizing fluorescent dye doped core-shell organosilicate nanoparticles with excellent size uniformity and water...

chapter

A non-iterative localization approach based on multi-dimensional scaling method for wireless sensor networks

Lichuan Liu, Kavitha Kavitha Guntaka

Proceedings of the 11th IEEE International Conference on Networking, Sensing and Control > 328 - 333

2014 IEEE 11th International Conference on Networking, Sensing and Control (ICNSC)

The location information of the sensor node is very important and should be known by the end user to take full advantage of the sensor network. In this paper, we proposed a non-iterative localization approach for wireless sensor network (WSN) using multi-dimensional scaling (MDS) method. MDS offers various advantages. It is robust to environmental errors, provides accurate localization, and calculates...

chapter

An Hybrid Senor Localization Algorithm for Wireless Sensor Networks

Lichuan Liu, Geetha Mavidi

2013 IEEE International Conference on Systems, Man, and Cybernetics > 1087 - 1092

2013 IEEE International Conference on Systems, Man and Cybernetics (SMC 2013)

chapter

Wireless communication integrated active noise control system for infant incubators

Lichuan Liu, Sen M. Kuo

2013 IEEE International Conference on Acoustics, Speech and Signal Processing > 375 - 378

ICASSP 2013 - 2013 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)

Every year, 20 million premature, low-birth-weight, very ill babies are born and most of them are saved by infant incubators. However, the high-level noise inside the incubator results in numerous adverse health effects. It is also difficult for parents bonding with their baby placed in an incubator inside neonatal intensive care unit (NICU). This paper presents a wireless communication integrated...

chapter

Infant cry classification integrated ANC system for infant incubators

Lichuan Liu, Kevin Kuo, Sen M. Kuo

2013 10th IEEE INTERNATIONAL CONFERENCE ON NETWORKING, SENSING AND CONTROL (ICNSC) > 383 - 387

2013 IEEE 10th International Conference on Networking, Sensing and Control (ICNSC)

The high noise level inside the infant incubator results in numerous adverse health effects for premature newborns and the active noise control (ANC) systems are developed to reduce the noise. This paper proposes an infant cry classification integrated ANC system for infant incubators. The developed system can dramatically reduce the harmful noise level, and the integrated infant cry detector and...

article

Validation and application of a liquid chromatography–tandem mass spectrometric method for the determination of GDC‐0834 and its metabolite in human plasma using semi‐automated 96‐well protein precipitation

Young G. Shin, Steve A. Jones, Stan C. Murakami, Lichuan Liu, more

Biomedical Chromatography > 26 > 11 > 1444 - 1451

A liquid chromatographic–tandem mass spectrometric (LC‐MS/MS) method was developed and validated for the determination of GDC‐0834 and its amide hydrolysis metabolite (M1) in human plasma to support clinical development. The method consisted of semi‐automated 96‐well protein precipitation extraction for sample preparation and LC‐MS/MS analysis in positive ion mode using TurboIonSpray® for analysis...

chapter

Female friendly DSP curriculum for expanding women's opportunities

Lichuan Liu

2012 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP) > 2757 - 2760

ICASSP 2012 - 2012 IEEE International Conference on Acoustics, Speech and Signal Processing

The paper presents a female -friendly engineering education in digital signal processing (DSP) at Northern Illinois University (NIU), more generally, revising the negative value traditionally placed upon electrical engineering achievement for women. Important tasks are as follows: (1) Design the DSP curricula in female-friendly way. (2) Establish an interactive DSP learners' community by developing...

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Keywords

WIRELESS SENSOR NETWORKS (12)
EQUATIONS (7)
ACTIVE NOISE CONTROL (6)
FREQUENCY MODULATION (5)
GLOBAL POSITIONING SYSTEM (5)
LOCATION (5)
MATHEMATICAL MODEL (5)
MICROPHONES (4)
WIRELESS SENSOR NETWORK (4)
ACCURACY (3)
AD HOC NETWORKS (3)
BLOCK CODES (3)
INFANT INCUBATOR (3)
LOCALIZATION (3)
LOCATION INFORMATION ACQUISITION (3)
MARKOV PROCESSES (3)
NETWORK THROUGHPUT (3)
NOISE REDUCTION (3)
RADIO DIRECTION-FINDING (3)
SENSORS (3)
SPACE-TIME CODES (3)
TIME FREQUENCY DIFFERENCE ARRIVAL (3)
AUTOMATION (2)
BONDING (2)
BRIDGES (2)
CHANNEL CODING (2)
COMPUTATIONAL COMPLEXITY (2)
COMPUTATIONAL MODELING (2)
CONFERENCES (2)
DIVERSITY RECEPTION (2)
END-TO-END DELAY (2)
ENERGY CONSUMPTION (2)
ESTIMATION (2)
FADING CHANNELS (2)
FREQUENCY ESTIMATION (2)
GE HEALTHCARE (2)
GENERAL NODES (UNKNOWN LOCATION) (2)
GIRAFFE INCUBATOR (2)
HYBRID OPTIMIZING METHOD (2)
INFANT INCUBATORS (2)
ITERATIVE METHODS (2)
KINASE INHIBITOR (2)
LINEAR FREQUENCY MODULATION CONTINUOUS WAVE (2)
LINEAR FREQUENCY MODULATION CONTINUOUS WAVE TECHNIQUE (2)
MARKOV CHAIN MODEL (2)
MOBILE RADIO (2)
NOISE CANCELLATION (2)
PEDIATRICS (2)
PHARMACOKINETICS (2)
POSITIONING (2)
POSITIONING METHOD (2)
QUEUEING THEORY (2)
RECEIVERS (2)
RHEUMATOID ARTHRITIS (2)
ROUTING PROTOCOLS (2)
SENSOR PLACEMENT (2)
SPACE DIVERSITY (2)
SYNCHRONIZATION (2)
TELECOMMUNICATION NETWORK ROUTING (2)
TFDA (2)
TIME FREQUENCY ANALYSIS (2)
TIME-FREQUENCY ANALYSIS (2)
TIME-OF-ARRIVAL ESTIMATION (2)
USA COUNCILS (2)
WIRELESS COMMUNICATION (2)
WSN (2)
3D POSITIONING (1)
3D SELF-POSITIONING METHOD (1)
A BASED PARALLEL ROUTING METHOD (1)
ACCESS PROTOCOLS (1)
ACCURATE FAULT ISOLATION (1)
ACTIVE NOISE CONTROL SYSTEM (1)
ACTIVE NOISE REDUCTION (1)
ACTUATOR CONTROL SIGNAL (1)
ACTUATOR FAILURES (1)
ACTUATORS (1)
AD HOC INTERVEHICLE COMMUNICATION (1)
AD HOC WIRELESS NETWORK (1)
ADAPTIVE FILTERS (1)
ALKYNES (1)
ALTITUDE HOLD MODE (1)
AMIDE HYDROLYSIS (1)
ANTENNA ARRAY (1)
ANTENNA ARRAYS (1)
ARRAYS (1)
AUTOMATED HIGHWAYS (1)
BANDWIDTH (1)
BASIC PH MODIFIER (1)
BATCH LOADING CONTROL SYSTEM (1)
BATCH LOADING FLOW RATE SEQUENCE (1)
BATCH PROCESSING (INDUSTRIAL) (1)
BAYES RULES (1)
BIOACOUSTICS (1)
BRUTON’S TYROSINE KINASE (1)
BRUTON’S TYROSINE KINASE (BTK) (1)
BTK (1)
CAPACITANCE (1)
CAUSALITY CONSTRAINT (1)
CHAN METHOD (1)
CHANNEL ESTIMATION (1)
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ieee (28)
Elsevier (5)
Wiley (5)
Springer (4)
ACS (1)

INFONA - science communication portal

Search results for: Lichuan Liu

Rhodium‐Catalyzed Intermolecular Silylation of C_sp−H by Silacyclobutanes

Assessment of OATP transporter‐mediated drug–drug interaction using physiologically‐based pharmacokinetic (PBPK) modeling – a case example

Correction to: Application of a Novel ‘Make and Test in Parallel’ Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects

Application of a Novel ‘Make and Test in Parallel’ Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects

Effect of OATP1B1/1B3 Inhibitor GDC‐0810 on the Pharmacokinetics of Pravastatin and Coproporphyrin I/III in Healthy Female Subjects

Effect of Microenvironmental pH Modulation on the Dissolution Rate and Oral Absorption of the Salt of a Weak Acid – Case Study of GDC-0810

Wireless communication integrated hybrid active noise control system for infant incubators

Best practices for the use of itraconazole as a replacement for ketoconazole in drug–drug interaction studies

Discovery of highly potent and selective Bruton’s tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability

Multi-channel ANC system using optimized reference microphones based on time difference of arrival

Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834

Hybrid Localization Algorithm in Wireless Sensor Networks and ITS Application in Building Monitoring

Structural differentiation of common bacteria using impedance spectroscopy

Novel route towards large scale synthesis of bright, water dispersible core-shell fluorescent dye doped organosilicate nanoparticles

A non-iterative localization approach based on multi-dimensional scaling method for wireless sensor networks

An Hybrid Senor Localization Algorithm for Wireless Sensor Networks

Wireless communication integrated active noise control system for infant incubators

Infant cry classification integrated ANC system for infant incubators

Validation and application of a liquid chromatography–tandem mass spectrometric method for the determination of GDC‐0834 and its metabolite in human plasma using semi‐automated 96‐well protein precipitation

Female friendly DSP curriculum for expanding women's opportunities

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