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Purpose Neuropeptide Y (NPY) is neuroprotective and can regulate inflammation. In the retina, microglia (MG) activation has been implicated in the pathogenesis of several diseases. We investigated whether NPY, particularly through Y1 receptor (Y1r) activation, is neuroprotective and modulates pro‐inflammatory responses in the retina.
Methods Immunocytochemistry, RT‐PCR, TUNEL and ELISA were used....
Purpose Calcium dobesilate (CaD) is used in the treatment of diabetic retinopathy, but its mechanism of action is not completely elucidated. We investigated the molecular and cellular mechanisms underlying the protective effects of CaD against the blood‐retinal barrier (BRB) breakdown induced by diabetes.
Methods Wistar rats were divided into: controls, diabetic (1 month diabetes duration) and diabetic...
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