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J. Neurochem. (2010) 114, 1460–1475.
AbstractAbnormal hyperexcitability of primary sensory neurons plays an important role in neuropathic pain. Voltage‐gated potassium (Kv) channels regulate neuronal excitability by affecting the resting membrane potential and influencing the repolarization and frequency of the action potential. In this study, we determined changes in Kv channels in dorsal root ganglion...
J. Neurochem. (2010) 112, 162–172.
AbstractDiabetic neuropathic pain is associated with increased glutamatergic input in the spinal dorsal horn. Group I metabotropic glutamate receptors (mGluRs) are involved in the control of neuronal excitability, but their role in the regulation of synaptic transmission in diabetic neuropathy remains poorly understood. Here we studied the role of spinal mGluR5...
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