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Progastrin-releasing peptide (ProGRP) is a specific and actively secreted product from small-cell lung carcinoma (SCLC) cells. Recently, an enzyme-linked immunosorbent assay, which uses monoclonal and polyclonal antibodies to recombinant ProGRP(31-98), a common region of ProGRP, was established. We measured concentrations of ProGRP(31-98), neuron-specific enolase (NSE) and carcinoembryonic antigen...
We have treated unresectable lung cancer patients with CDDP + IFX + VDS for squamous cell carcinoma, and CDDP + IFX + ETP for small-cell lung cancer. Bone marrow toxicity was moderately severe. To lessen toxicity and maintain the schedule of treatment courses, we administered rhG-CSF from February, 1992 to September, 1993. rhG-CSF was given for 14 days from day 8 in the 1st course and from day 4...
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