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Tumor suppressor genes (TSGs) are a class of genes that play key roles in cancer induction and development. A comprehensive investigation of TSGs in protein-protein interaction (PPI) networks may expand our understanding on their roles in cancer development. In this study, we first collected reliable human TSG lists from tumor suppressor gene database. To provide an unbiased network view, we mapped...
Protein–protein interaction (PPI) network analysis has been widely applied in the investigation of the mechanisms of diseases, especially cancer. Recent studies revealed that cancer proteins tend to interact more strongly than other categories of proteins, even essential proteins, in the human interactome. However, it remains unclear whether this observation was introduced by the bias towards more...
It has been commonly accepted that protein-protein interaction network contains valuable information for elucidation of biological processes. Such information, which is difficult to be identified from traditional genetic studies, is important for uncovering the mechanisms of complex diseases such as cancers. In this study, we performed a systematic analysis of global network characteristics for the...
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