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It has been well recognized that adverse drug reactions (ADRs) are a significant cause of morbidity and mortality. There is a growing interest in investigating biological pathways involved in cellular response to drugs. Based on examining the co-occurrence of drugs in pathway activity and ADR profiles, in this paper, we propose a new method to explore the relationship between biological pathways and...
Recent studies have demonstrated that gene set analysis, which tests disease association with genetic variants in a group of functionally related genes, is a promising approach for analyzing and interpreting genome-wide association studies (GWAS) data. These approaches aim to increase power by combining association signals from multiple genes in the same gene set. In addition, gene set analysis can...
Unlike the typical analysis of single markers in genome-wide association studies (GWAS), we incorporated Gene Set Enrichment Analysis (GSEA) and hypergeometric test and combined them using Fisher's combined method to perform pathway-based analysis in order to detect genes' combined effects on mediating schizophrenia. A few pathways were consistently found to be top ranked and likely associated with...
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