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Background
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are the most frequent triggers of drug hypersensitivity with NSAIDs‐induced urticaria/angioedema (NIUA) the most common phenotype. Loss of hypersensitivity has been reported for IgE‐mediated reactions; however, it has not been assessed in nonimmunological reactions such as NIUA. We evaluated NSAID‐hypersensitivity over time in NIUA patients...
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are the drugs most frequently involved in allergic reactions of which two main types exist: IgE‐mediated and crossintolerance. The diagnosis of crossintolerance reactions is often based on the drug provocation test. The potential value of the basophil activation test (BAT) was evaluated using different basophil markers in the diagnosis of patients with...
BackgroundNonsteroidal anti‐inflammatory drugs (NSAIDs) are the most frequent medicaments involved in drug hypersensitivity reactions, with NSAID‐induced urticaria/angioedema (NIUA) being the most frequent clinical entity. The natural evolution of NIUA has been suggested to lead to chronic urticaria (CU) in an important proportion of patients, such that NIUA may therefore precede CU. Our aim was to...
Hypersensitivity reactions to aspirin (acetylsalicylic acid) and other nonsteroidal anti‐inflammatory drugs (NSAIDs) constitute only a subset of all adverse reactions to these drugs, but due to their severity pose a significant burden to patients and are a challenge to the allergist. In susceptible individuals, NSAIDs induce a wide spectrum of hypersensitivity reactions with various timing, organ...
BackgroundMultiple NSAID‐induced urticaria/angioedema (MNSAID‐UA) is an entity well differentiated from aspirin‐exacerbated respiratory disease (AERD), although no detailed phenotype analysis has yet been performed. The objective was to evaluate the functional characteristics of MNSAID‐UA subjects by analyzing the response to nasal lysine–aspirin challenge and measurement of nasal inflammatory mediator...
To cite this article: Doña I, Blanca‐López N, Jagemann LR, Torres MJ, Rondón C, Campo P, Gómez AI, Fernández J, Laguna JJ, Rosado A, Blanca M, Canto G. Response to a selective COX‐2 inhibitor in patients with urticaria/angioedema induced by nonsteroidal anti‐inflammatory drugs. Allergy 2011; 66: 1428–1433.
AbstractBackground: In subjects with hypersensitivity reactions with cross‐intolerance to...
To cite this article: Kowalski ML, Makowska JS, Blanca M, Bavbek S, Bochenek G, Bousquet J, Bousquet P, Celik G, Demoly P, Gomes ER, Niżankowska‐Mogilnicka E, Romano A, Sanchez‐Borges M, Sanz M, Torres MJ, De Weck A, Szczeklik A, Brockow K. Hypersensitivity to nonsteroidal anti‐inflammatory drugs (NSAIDs) – classification, diagnosis and management: Review of the EAACI/ENDA and GA2LEN/HANNA. Allergy...
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