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Operationally and user-simple a highly efficient one-pot three-component (5 molecules) coupling of α-enolic dithioesters, cysteamine hydrochloride and aldehydes afforded a range of thiazolopyridines in high yields under metal-free and solvent-free conditions. The new domino protocol generated two rings by the concomitant formation of seven multiple bonds (two C–C, three C–N and two C–S) involving...
A rapid and efficient one-pot three-component protocol for the synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11-triones 4 and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones 6 has been developed by domino coupling of phthalhydrazide, 1,3-diketones, and aldehydes under solvent-free conditions at 80°C as well as under solvent-free ultrasound irradiation at room temperature promoted by (S)-camphorsulfonic...
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